Synthesis, Invivo Analgesic and Invitro Anti-microbial Activity Of3-amino-4-[2- (substituted Phenyl) Hydrazin-1-ylidene]-1-[(2- Oxo-2h-chromen-3-yl) Carbonyl]-4, 5-dihydro-1h- Pyrazol-5-one and Its Schiff Bases
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چکیده
A series of 3-amino-4-[2-(4-chlorophenyl)hydrazin-1-ylidene]-1-[(2-oxo-2H-chromen-3-yl)carbonyl]4,5-dihydro-1H-pyrazol-5-one (4a-j) and its Schiff bases (5a-i) have been synthesized. The structures of the newly synthesized compounds were confirmed by IR, NMR and Mass spectral analysis. The titled compounds were screened for their invivoanalgesic activity by acetic acid-induced writhing model in mice. All compounds were evaluated for their invitro anti-bacterial and anti-fungal activity. Among the synthesized compounds, compounds 4f, 4g demonstrated 1.06 times more potent anti bacterial activity aganistE coil and K. pneumoniaeand corresponding Schiff base compounds 5d and 5edemonstrated 1.00 and 1.06 times more potent anti bacterial activity aganistE coil. Compounds 4b and 4c displayequipotent anti-fungal activity aganistC. albicans and A. niger. Compound5ishowing 1.04 times more potent than standard Indomethacin and also the compounds 4f, 4g, 5b, and 5j exhibited significant analgesic activity compared with the standard drug (Indomethacin0.03 mM/kg) on oral administration.
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